diff --git a/ethers-core/src/types/signature.rs b/ethers-core/src/types/signature.rs
index bf21b14b..959c0d33 100644
--- a/ethers-core/src/types/signature.rs
+++ b/ethers-core/src/types/signature.rs
@@ -1,6 +1,6 @@
 // Code adapted from: https://github.com/tomusdrw/rust-web3/blob/master/src/api/accounts.rs
 use crate::{
-    types::{Address, H256},
+    types::{Address, H256, U256},
     utils::hash_message,
 };
 
@@ -55,9 +55,9 @@ pub enum RecoveryMessage {
 /// An ECDSA signature
 pub struct Signature {
     /// R value
-    pub r: H256,
+    pub r: U256,
     /// S Value
-    pub s: H256,
+    pub s: U256,
     /// V value in 'Electrum' notation.
     pub v: u64,
 }
@@ -118,8 +118,12 @@ impl Signature {
     fn as_signature(&self) -> Result<(RecoverableSignature, RecoveryId), SignatureError> {
         let recovery_id = self.recovery_id()?;
         let signature = {
-            let gar: &GenericArray<u8, U32> = GenericArray::from_slice(self.r.as_bytes());
-            let gas: &GenericArray<u8, U32> = GenericArray::from_slice(self.s.as_bytes());
+            let mut r_bytes = [0u8; 32];
+            let mut s_bytes = [0u8; 32];
+            self.r.to_big_endian(&mut r_bytes);
+            self.s.to_big_endian(&mut s_bytes);
+            let gar: &GenericArray<u8, U32> = GenericArray::from_slice(&r_bytes);
+            let gas: &GenericArray<u8, U32> = GenericArray::from_slice(&s_bytes);
             let sig = K256Signature::from_scalars(*gar, *gas)?;
             RecoverableSignature::new(&sig, recovery_id)?
         };
@@ -163,8 +167,8 @@ impl<'a> TryFrom<&'a [u8]> for Signature {
         }
 
         let v = bytes[64];
-        let r = H256::from_slice(&bytes[0..32]);
-        let s = H256::from_slice(&bytes[32..64]);
+        let r = U256::from_big_endian(&bytes[0..32]);
+        let s = U256::from_big_endian(&bytes[32..64]);
 
         Ok(Signature { r, s, v: v.into() })
     }
@@ -183,8 +187,12 @@ impl FromStr for Signature {
 impl From<&Signature> for [u8; 65] {
     fn from(src: &Signature) -> [u8; 65] {
         let mut sig = [0u8; 65];
-        sig[..32].copy_from_slice(src.r.as_bytes());
-        sig[32..64].copy_from_slice(src.s.as_bytes());
+        let mut r_bytes = [0u8; 32];
+        let mut s_bytes = [0u8; 32];
+        src.r.to_big_endian(&mut r_bytes);
+        src.s.to_big_endian(&mut s_bytes);
+        sig[..32].copy_from_slice(&r_bytes);
+        sig[32..64].copy_from_slice(&s_bytes);
         // TODO: What if we try to serialize a signature where
         // the `v` is not normalized?
         sig[64] = src.v as u8;
diff --git a/ethers-signers/src/aws/utils.rs b/ethers-signers/src/aws/utils.rs
index 149b66d7..7b98ec5a 100644
--- a/ethers-signers/src/aws/utils.rs
+++ b/ethers-signers/src/aws/utils.rs
@@ -13,7 +13,7 @@ use ethers_core::{
         elliptic_curve::sec1::ToEncodedPoint,
         FieldBytes,
     },
-    types::{Address, Signature as EthSig, H256},
+    types::{Address, Signature as EthSig, U256},
     utils::keccak256,
 };
 use rusoto_kms::{GetPublicKeyResponse, SignResponse};
@@ -26,8 +26,8 @@ pub(super) fn rsig_to_ethsig(sig: &RSig) -> EthSig {
     let v = (v + 27) as u64;
     let r_bytes: FieldBytes = sig.r().into();
     let s_bytes: FieldBytes = sig.s().into();
-    let r = H256::from_slice(&r_bytes.as_slice());
-    let s = H256::from_slice(&s_bytes.as_slice());
+    let r = U256::from_big_endian(&r_bytes.as_slice());
+    let s = U256::from_big_endian(&s_bytes.as_slice());
     EthSig { r, s, v }
 }
 
diff --git a/ethers-signers/src/ledger/app.rs b/ethers-signers/src/ledger/app.rs
index 2579b3df..0a02294f 100644
--- a/ethers-signers/src/ledger/app.rs
+++ b/ethers-signers/src/ledger/app.rs
@@ -170,8 +170,8 @@ impl LedgerEthereum {
         }
 
         let v = result[0] as u64;
-        let r = H256::from_slice(&result[1..33]);
-        let s = H256::from_slice(&result[33..]);
+        let r = U256::from_big_endian(&result[1..33]);
+        let s = U256::from_big_endian(&result[33..]);
         Ok(Signature { r, s, v })
     }
 
diff --git a/ethers-signers/src/wallet/mod.rs b/ethers-signers/src/wallet/mod.rs
index 53d3a294..bf4d0876 100644
--- a/ethers-signers/src/wallet/mod.rs
+++ b/ethers-signers/src/wallet/mod.rs
@@ -16,7 +16,7 @@ use ethers_core::{
         elliptic_curve::FieldBytes,
         Secp256k1,
     },
-    types::{transaction::eip2718::TypedTransaction, Address, Signature, H256},
+    types::{transaction::eip2718::TypedTransaction, Address, Signature, H256, U256},
     utils::hash_message,
 };
 use hash::Sha256Proxy;
@@ -116,8 +116,8 @@ impl<D: DigestSigner<Sha256Proxy, RecoverableSignature>> Wallet<D> {
 
         let r_bytes: FieldBytes<Secp256k1> = recoverable_sig.r().into();
         let s_bytes: FieldBytes<Secp256k1> = recoverable_sig.s().into();
-        let r = H256::from_slice(r_bytes.as_slice());
-        let s = H256::from_slice(s_bytes.as_slice());
+        let r = U256::from_big_endian(r_bytes.as_slice());
+        let s = U256::from_big_endian(s_bytes.as_slice());
 
         Signature { r, s, v }
     }